Database of multiple alignments  

Multiple alignment database is produced to have readily available high quality alignments. The advantages of using multiple sequence alignment is database searches is that more information is used, which results in higher sensitivity compared with pair wise searches.

PSI-BLAST is a hybrid database which uses elements of both pair wise and multiple sequence alignment methods. In PSI (Position Specific Iterated) BLAST, it allows automatic arrangement of position specific sequences. Main disadvantage of PSI-BLAST is that automatic iteration may lead to errors some times.

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